If you're in the market for a new set of stereo desktop speakers, check out Cnet's list of their favorite 2.0 and 2.1 models. Of their picks, the M-Audio Studiophile AV40 stands out as a worthwhile choice for audiophiles. Some of their other choices like the Altec Lansing Expressionist Bass and Logitech Z-5 - not so much.
If you can afford to spend $200 or more, there are even better choices available than the M-Audio. The Audioengine A2 and A5 are great options, but my personal favorite is the Swan M200, in either MKII ($250) or MKIII ($400) guise.